In an effort to streamline the development and production of pharmaceuticals based on a specific biological protein, scientists at Rice University in Houston have recently been developing a technique of purification and separation. Researchers have shown that altering the protein’s concentration may alter how it interacts with a nylon membrane. There is still a long way to go, but they believe that if they can streamline this aspect of the process, they can reduce the cost and time it takes to bring vital pharmaceuticals to market.
Multiple tasks and operations rely heavily on Chromatography Refrigerator. You probably already know that your researchers need a chilly place to keep their materials if they are working in this field. While it’s possible to do so in a cold room, doing so presents a few challenges, including the necessity to keep some parts of the equipment utilized at ambient temperature and the inherent limitations posed by the lack of dedicated space. A new chromatographic refrigerator, which may serve as your own small research laboratory, is a superior answer for your researchers’ convenience, efficiency, and productivity. From Global Lab Supply such products are properly obtainable now.
Have you ever experienced an HPLC system failing during a run due to a faulty component or lack of maintenance?
- Your HPLC is similar to your home appliances in that it will operate more smoothly and perform better with regular maintenance, cleaning, and servicing.
- You wouldn’t expect your refrigerator to survive very long if the coils and compressor seals were dusty and worn out. In the same way, you can’t expect an instrument to provide accurate results without proper maintenance.
- Do your homework and set aside some time before your holiday break to get your lab ready for the next year; good lab practise is essential to any successful research facility.
Here are seven simple steps you can take now to ensure your lab’s continued success in the new year
Suspect pumps: A reliable HPLC or UHPLC separation relies on a pump that has been properly maintained. You should inspect the buffer for precipitation, the leak sensor, the rear seal wash hose, and the timing of the next maintenance service.
Wash opulent bottles and swap over their stoppers
Plastics degrade over time when exposed to organic solvents or acids, which are naturally flammable. One easy and effective method of preserving the integrity of your essences is to use clean bottles and new frits from the outset. This will help to reduce the amount of water vapour absorbed from the air. Hydrocarbohydrate solvents absorb water vapour, too. Now that Chromatography Refrigerator by Global Lab Supplies get the right products, you can expect the best.
Columns should be washed and stored properly
All methods should include steps for cleaning UHPLC and HPLC columns. The solutions you use will be specific to your application; see the user manuals for your column for specifics. The best method is to keep track of your columns in a logbook or electronic record with the use of column ID tags. If you won’t be using your HPLC system for an extended period of time, you should run isopropyl alcohol through it before you leave for the holidays. When you return, you’ll need to flush the system and re-purge the new solutions you added.
Use a cleaning solution to flush the system
In addition to the sample injector needle and detector flow cell needle, there are a number of other hardware components that are required.
Apply a system appropriateness test: Test your system’s appropriateness after any maintenance to make sure your instrument is working properly (SST). Develop an SST procedure immediately if you do not already have one. You may easily create an automated SST with the use of advanced chromatography software like Thermo Scientific’s TM Chromatic Determination System (CDS).
Throw out old chemicals
Certain chemicals, such as those that degrade in the presence of light or oxygen, have a shelf life. This includes both light-sensitive and redox-active chemicals, as well as inert gas-packed compounds and liquid buffers. Verify the use-by dates on all of your chemicals and safely dispose of those that have passed their use-by dates.
Spending time and money wisely in the lab is always a good idea
Congratulations if your lab already engages in extreme routine maintenance! Keep this list close by in case you need to double check anything at the last minute, and feel free to distribute it to any new coworkers who may find it useful.